Solution State NMR Spectroscopy


I was first introduced to solution state NMR spectroscopy during my undergraduate studies in chemistry. At the time, I was working on a project in which I was trying to characterise a new molecule that I had synthesised. I was using a variety of techniques, including mass spectrometry and IR spectroscopy, but I was having difficulty getting a clear picture of the molecule’s structure. My supervisor suggested that I try solution state NMR spectroscopy, and I was immediately intrigued.

I began by reading up on the basics of NMR spectroscopy. I quickly realised that this was a powerful tool that could provide a wealth of information about a molecule’s structure. I was particularly interested in the way that NMR spectroscopy could be used to characterise the different types of bonds present in a molecule.

I carried out my first experiment using solution state NMR spectroscopy on a sample of my synthesised molecule. I was able to obtain a clear signal for the molecule, and I was able to identify the different types of bonds present. This was a major breakthrough in my project, and it allowed me to finally characterise my molecule.

Since that first experiment, I have used solution state NMR spectroscopy on many occasions. It has become one of my favourite techniques, and I always find it fascinating to see the different types of information that can be obtained from an NMR spectrum. I am now a PhD student, and I am using solution state NMR spectroscopy to study a variety of different molecules. I am confident that this technique will continue to be a valuable tool in my research.


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